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March 16, 20260 citations

Exploring the Mechanism of Selenium-Biofortified Polygonatum Kingianum in Alzheimer's Disease: An Integrated Metabolomics and Network Pharmacology In Silico Study.

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ZJZixuan JiaQXQiang XiaoGSGuangdi Shi

Key Points

  • The aim is to uncover the mechanisms by which selenium-biofortified Polygonatum Kingianum affects Alzheimer's disease using advanced methodologies.
  • Established a predictive framework combining metabolomics and network pharmacology.
  • Conducted in silico analysis to identify candidate compounds and pathways.
  • Prioritized targets for further experimental validation.
  • Identified multiple pathways involved in the effects of selenium-biofortified Polygonatum Kingianum.
  • Suggested specific candidate compounds for future studies.
  • Provided a methodological paradigm for natural product research in neurodegeneration.

Abstract

This study establishes a predictive "metabolomics-network pharmacology- dynamics" framework for elucidating the multi-target mechanisms of Se-PK against AD. While providing a methodological paradigm for natural product research, these in silico findings prioritize candidate compounds and pathways for future experimental validation, advancing precision phytotherapy in neurodegeneration.

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Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/69b79e968166e15b153ac0e8https://doi.org/10.2174/0113862073411991251130085435
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