GFAP can be reliably measured in serum and plasma of Danish adults, while UCH-L1 measurement in plasma requires further evaluation for its suitability.
Serum and plasma are suitable for GFAP measurement, but UCH-L1 should not be measured in plasma, and population-specific cutoff values are needed for accurate assessment.
The analytical precision and storage conditions of GFAP/UCH-L1 were satisfactory. Serum and plasma can be used for measurement of GFAP, whereas UCH-L1 measurement in plasma is not advised until further evaluations are conducted. The manufacturer's upper reference limits may not be suitable for our population. Thorough research on cutoff values is necessary.
Andersen et al. (2026) studied this question. GFAP can be reliably measured in serum and plasma of Danish adults, while UCH-L1 measurement in plasma requires further evaluation for its suitability.