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March 17, 2026Cardiovascular Diabetology8 citationsOpen Access

Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis

YZYuting ZhangBLBei LiuYZYuan Zhu

Key Points

  • To explore the relationship between cumulative exposure and changes in the cholesterol-HDL-glucose index with cardiovascular disease risk in older adults.
  • Conducted a longitudinal analysis of middle-aged and older adults
  • Monitored cholesterol, HDL, and glucose levels over time
  • Assessed CVD risk in relation to CHG index changes.
  • Higher cumulative CHG levels correlate with increased CVD risk
  • Consistent high-risk CHG levels significantly elevate CVD risk
  • Long-term monitoring may help mitigate CVD risk.

Abstract

Our research indicates that both cuCHG and CHG changes are associated with CVD risk in middle-aged and older adults, particularly for those with consistently high-risk CHG levels, which are linked to a significantly increased CVD risk. In clinical practice, monitoring long-term CHG changes and maintaining relatively stable levels may help prevent CVD in this population.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef52deb47d591b8c55e9https://doi.org/10.1186/s12933-026-03137-9
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