This review explores the structure and immune roles of the meninges in CNS diseases, highlighting new therapeutic targets.
Key Points
This review aims to summarize the structural and functional aspects of the meninges as a neuroimmune interface, particularly in relation to CNS diseases.
Review of anatomical and molecular studies regarding meningeal structure and function.
Analysis of barrier characteristics and immune cell interactions in the meninges.
Discussion of meningeal dysfunction in bacterial meningitis, multiple sclerosis, and Alzheimer’s disease.
The meninges are revealed to have complex and heterogeneous barrier architecture.
Impaired meningeal function is linked to disease progression in multiple neurological disorders.