Alpha-synuclein aggregation in Parkinson's disease has resisted three decades of therapeutic approaches. This paper applies geometric structural decomposition using the OMUO Genesis Engine's Reverse Genesis capability to identify what must be structurally true before any solution is possible. The analysis produced 386 structural nodes across 8 root decomposition paths, identifying three non-obvious reframings: (1) seedproof membrane handshake — intercepting prion-like templating at the vesicle fusion interface; (2) pathological shape memory — targeting folding rule-propagation rather than conformation; and (3) kinetic trap design with path-dependent frustration. The analysis independently confirmed liquid-liquid phase separation as a critical intervention layer through purely geometric reasoning.
Gedas Mekšriūnas (2026) studied this question.