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December 21, 2010Circulation196 citationsOpen Access

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

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WWWei WuAMAntoine MuchirJSJian Shan

Structured PICO

Do Mitogen-Activated Protein Kinase Inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by LMNA mutations?

P
Population
Cardiomyopathy caused by mutation in Lamin A/C (LMNA) gene
I
Intervention
Mitogen-Activated Protein Kinase Inhibitors (ERK and JNK signaling inhibitors)
O
Outcome
Heart function and fibrosissurrogate

ERK and JNK signaling inhibitors show potential for treating cardiomyopathy caused by LMNA mutations by improving heart function and preventing fibrosis.

Abstract

Inhibitors of ERK and JNK signaling could potentially be used to treat humans with cardiomyopathy caused by LMNA mutations.

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Cite This Study

Wu et al. (2010) studied this question.

synapsesocial.com/papers/69bd604be24527382fc7e203https://doi.org/10.1161/circulationaha.110.970673
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