Adults with isolated left ventricular non-compaction face a high risk of severe complications, transplantation, or death, highlighting the need for close follow-up despite frequent echocardiographic over-diagnosis.
In this large reported series of LVNC, we observed that: (i) Left ventricular non-compaction was detected by familial screening in asymptomatic patients in 8% of cases. (ii) Left ventricular non-compaction was frequently over-diagnosed by echocardiography. (iii) Patients identified as LVNC presented with a high risk of severe complications, transplantation or death and needed close follow-up.
Habib et al. (2010) studied this question.