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March 21, 2026Oncoscience0 citationsOpen Access

A low-cost color sensor device for rapid detection of high-grade serous ovarian carcinoma (HGSOC)

FIFaisal IqbalUniversity of Illinois Chicago

Key Points

  • The study aims to develop a low-cost color sensor device for the rapid detection of high-grade serous ovarian carcinoma (HGSOC).
  • Developed a colorimetric method based on nucleic acid amplification.
  • Used inorganic pyrophosphatase to hydrolyze pyrophosphate into inorganic phosphate.
  • Created phosphomolybdate precipitate reacting with inorganic phosphate for color change.
  • Employed RGB LEDs for object illumination and color detection using a microcontroller.
  • Integrated data conversion and display via a graphical user interface.
  • Successfully detected color changes in samples indicating the presence of HGSOC.
  • Demonstrated that the Ercose device is quick, lightweight, and cost-effective.
  • Showed the capability for real-world applications where traditional spectrophotometers are impractical.

Abstract

A sensitive nucleic acid detection approach based on tracing the inorganic phosphate (Pi) created during amplification by means of the colorimetric method has been presented.This method relies on nucleic acid amplification.Pyrophosphate (PPi), a result of the nucleic acid polymerization reaction, was hydrolyzed into inorganic phosphate (Pi) by the addition of inorganic pyrophosphatase.To create the phosphomolybdate precipitate, the obtained Pi could react with acid molybdate.The color of amplified sample was changed into green.Using high grade serous ovarian carcinoma (HGSOC) as an example, this tactic's usefulness was proven.Here, describe the Ercose (Eraser + Color Sensor) device proof-of-concept, which uses a straightforward strategy without sacrificing the accuracy of the outcomes.Ercose is a simple, quick, weightless and inexpensive.A low-cost, user-friendly color sensor is suggested for development in this study to identify the hue of the objects.The test objects were progressively illuminated by the sensor's RGB light emitting diodes, which served as the light sources.The analogue voltage data were converted to digital form and serially delivered to a graphical user interface (GUI).To determine the test objects colors, the digitized voltage values were employed (i.e., RGB values).The microcontroller arduino nano was managed by the GUI, which also showed the needed color values.The Ercose device can be used in a variety of real-world scenarios where standard spectrophotometer devices are not practical.

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Cite This Study

Faisal Iqbal (2026) studied this question.

synapsesocial.com/papers/69be34f26e48c4981c673232https://doi.org/10.18632/oncoscience.652
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