PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 21, 2026Clinical Cancer Research1 citations

Immunity, age, and luminal breast cancer: understanding the Holy Trinity

View Full Paper
RSR. SalgadoMKM. Kok

Key Points

  • The central aim is to explore the relationship between immune cell subtypes and survival in patients with luminal breast cancer.
  • Analyzed data from 390 patients with stage I-III breast tumors
  • Focused on hormone-receptor positive and HER2-negative cancers
  • Evaluated associations between tumor infiltrating lymphocytes and survival outcomes
  • Higher numbers of various tumor infiltrating lymphocyte subtypes linked to improved distant disease free survival
  • Improvements noted in overall survival at an 8-year follow-up
  • Both immunostimulatory and immunosuppressive TILs contributed positively to outcomes

Abstract

Abstract In 390 patients with stage I-III hormone-receptor positive/HER2-negative breast tumors higher number of Tumor Infiltrating Lymphocytes (TILs)-subtypes, regardless of whether they were immunostimulatory or immunosuppressive, including T-regulatory cells and CD8- and non-CD8 T-cells, are associated with improved distant disease free survival and overall survival at 8 years follow-up.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Salgado et al. (2026) studied this question.

synapsesocial.com/papers/69be38006e48c4981c6780c8https://doi.org/10.1158/1078-0432.ccr-25-4035
Ask AI
Helpful
Bookmark
Share
View Full Paper