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March 23, 2026Virologica Sinica0 citationsOpen Access

Identification of a novel HIV-1 circulating recombinant form (CRF161₀107) from CRF01AE-C5 lineage among men who have sex with men in southwestern China

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MCMin ChenHCHuichao ChenYMYanling Ma

Key Points

  • The aim is to identify and characterize a new HIV-1 circulating recombinant form among a specific population in China.
  • Genetic analysis to identify the novel recombinant form
  • Characterization of parental lineages CRF01_AE-C5 and CRF07_BC-N
  • Population focus on men who have sex with men in southwestern China
  • CRF161_0107 was identified as a novel recombinant form
  • It emerged around 2016 from specific parental lineages
  • This is the first report documenting its presence in the region, indicating HIV-1 evolution.

Abstract

• Identification of a novel HIV-1 circulating recombinant form (CRF161₀107) in Chinese men who have sex with men. • CRF161₀107 emerged around 2016, exhibiting unique CRF01AE-C5 and CRF07BC-N parental lineages. • This is the first report of a CRF derived from CRF01AE-C5 in southwestern China, suggesting viral migration. • The finding underscores the ongoing evolution of HIV-1 via recombination in key populations such as MSM.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69c0de74fddb9876e79c13b9https://doi.org/10.1016/j.virs.2026.03.008
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