Does exercise-based cardiac rehabilitation reduce NT-pro-BNP levels in patients with moderate left ventricular systolic dysfunction after myocardial infarction?
Exercise-based cardiac rehabilitation over three months improves surrogate markers including NT-pro-BNP and exercise capacity in post-MI patients with LV dysfunction.
Three months exercise training in patients with moderate left ventricular systolic dysfunction after myocardial infarction induced a reduction in NT-pro-BNP levels, an improvement of exercise capacity and early left ventricular diastolic filling, without negative left ventricular remodelling. Whether the reduction of NT-pro-BNP levels could be useful as a surrogate marker of favourable left ventricular remodelling at a later follow-up remains to be further explored.
Giallauria et al. (2006) studied this question.