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March 25, 2026RSC AdvancesOpen Access

Continuous-flow synthesis of Pd( ii )-anchored amino-functionalised magnetic silica nanoparticles as a robust recyclable catalyst for aqueous Sonogashira cross-coupling

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Authors

USUthai SakeeAMAekkaphon MokkaratWRWidchaya Radchatawedchakoon

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Overview

Research evaluates a magnetically recoverable palladium nanocatalyst for efficient Sonogashira reactions in water, suggesting a scalable synthesis process.

Key Points

  • This research aims to develop a recyclable palladium nanocatalyst for effective Sonogashira cross-coupling in aqueous environments.
  • Synthesis of Fe3O4@SiO2-NH2-Pd(II) using continuous-flow coprecipitation/silanisation
  • Evaluation of catalytic activity in Sonogashira reactions
  • Assessment of magnetic recoverability
  • The synthesized catalyst demonstrated high activity in water for Sonogashira cross-coupling
  • The palladium nanoparticles remained effective after multiple reaction cycles
  • The continuous-flow method provided a scalable approach for catalyst production

Cite This Study

Sakee et al. (2026) studied this question.

synapsesocial.com/papers/69c37b41b34aaaeb1a67d72fhttps://doi.org/10.1039/d6ra01007e
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