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March 25, 2026The Journal of Clinical Endocrinology & Metabolism2 citationsOpen Access

Evaluating the therapeutic impact of tirzepatide in people with partial lipodystrophy

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MMMandour O MandourASAnna StearsAKAgatha Van Der Klaauw

Key Points

  • The research aims to evaluate the effects of tirzepatide on weight and metabolic control in partial lipodystrophy.
  • Evaluate the effects of tirzepatide in individuals diagnosed with partial lipodystrophy.
  • Measure changes in weight, glycaemic control, serum triglycerides, and daily insulin requirement.
  • Tirzepatide led to significant reductions in weight.
  • Improvements in glycaemic control were observed.
  • Serum triglycerides decreased significantly.
  • The daily insulin requirement also reduced.

Abstract

In patients with partial lipodystrophy, tirzepatide use resulted in substantial statistically significant reductions in weight, glycaemic control, serum triglycerides and daily insulin requirement. We recommend further prospective studies to support these findings and to evaluate its impact earlier in the course of the disorder.

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Cite This Study

Mandour et al. (2026) studied this question.

synapsesocial.com/papers/69c37ba2b34aaaeb1a67e4aahttps://doi.org/10.1210/clinem/dgag126
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