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March 25, 2026Rapid Communications in Mass Spectrometry0 citations

Lingguizhugan Decoction Alleviates Lung Inflammatory in Obstructive Sleep Apnea by Modulating ROS and HIF‐1α Signaling Pathway Based on UHPLC–MS, Network Pharmacology, Transcriptomics, and Experimental Verification

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JLJinjin LiuSoochow UniversityLHLi HanShanghai University of Medicine and Health SciencesMLMengyu LiuShanghai University of Traditional Chinese Medicine

Key Points

  • Evaluate the effects of Lingguizhugan Decoction (LGZG) on lung inflammation in obstructive sleep apnea.
  • Conducted chronic intermittent hypoxia (CIH) experiments in mice.
  • Analyzed lung inflammation and immune response markers like IL-6.
  • Used UHPLC–MS, network pharmacology, and transcriptomics for comprehensive analysis.
  • LGZG alleviates CIH-induced pulmonary inflammation and neutrophil infiltration.
  • Significant reduction in IL-6 secretion observed.
  • Inhibition of reactive oxygen species (ROS) and HIF-1α signaling pathway noted.

Abstract

LGZG alleviates CIH-induced pulmonary inflammation, neutrophil infiltration, and IL-6 secretion in mice. These effects are associated with the suppression of ROS production and inhibition of the HIF-1α signaling pathway.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69c37bc2b34aaaeb1a67e79chttps://doi.org/10.1002/rcm.70064
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