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March 26, 2026Multiple Sclerosis and Related Disorders2 citationsOpen Access

Ocular toxicity associated with anti-CD20 monoclonal antibodies: A pharmacovigilance analysis using the FAERS database

YKYun KuangCentral South UniversityYGYAN GUOHunan Normal UniversityYLYaxin LiuCentral South University

Key Points

  • This research aims to examine the ocular toxicity associated with anti-CD20 monoclonal antibodies using the FAERS database.
  • Analyzed adverse event reports from the FAERS database
  • Identified reports related to anti-CD20 monoclonal antibodies
  • Classified and evaluated ocular adverse events
  • 86% of ocular adverse events were linked to a specific antibody
  • Ofatumumab contributed 11% and obinutuzumab 2% of reports
  • Over half of ocular adverse events occurred within 15 days of treatment initiation
  • All four anti-CD20 agents indicated signals for ocular infections, suggesting a potential class effect.

Abstract

contributed 86% of reports; ofatumumab 11%, obinutuzumab 2%. Over half of ocular AEs occurred within 15 days of treatment initiation. All four agents showed signals for ocular infections, suggesting a class effect.

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Cite This Study

Kuang et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc37fdc3bde4489177d1https://doi.org/10.1016/j.msard.2026.107158
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