21: Evaluating Predictive Performance of Pediatric Logistic Organ Dysfunction-2 Score in Trauma Patients

Introduction: Multiorgan dysfunction scoring systems, including the Pediatric Logistic Organ Dysfunction-2 (PELOD-2), are used to predict mortality in pediatric intensive care unit (PICU) populations. We have previously shown that the day 1 PELOD-2 score has good discrimination p< 0.001. The PELOD-2 scores had strong discrimination at day 1, day 3, and day 5 with AUROC values of 0.88 (95% confidence interval, (0.69 –1.0), 0.91(0.84 –0.89), and 0.96 (0.94 –0.99) and corresponding AUPRCs of 0.65 (0.47 -0.84), 0.88 (0.76 –0.96), and 0.79 (0.59 –0.94). Calibration of the PELOD-2 scores at day 1, day 3, and day 5 were also adequate at p=0.24, p=0.83, and p=0.93. Conclusions: The PELOD-2 score demonstrated strong discrimination and acceptable calibration at day 1, day 3, and day 5 post-trauma, indicating robust predictive performance for mortality in pediatric trauma patients. Validation of these results are required in larger multi-center populations. These findings support the use of PELOD-2 as an outcomes measure in future trauma-focused clinical trials.