What question did this study set out to answer?

To evaluate mortality risk and causes of death in individuals with exogenous Cushing's syndrome.

March 26, 2026Open Access

Mortality Risk and Causes of Death in Exogenous Cushing’s Syndrome: A Systematic Review and Meta-analysis

Key Points

To evaluate mortality risk and causes of death in individuals with exogenous Cushing's syndrome.
Conducted a systematic review and meta-analysis
Analyzed chronic oral glucocorticoid exposure
Evaluated correlations between treatment doses and mortality risk
Chronic oral glucocorticoid exposure linked to increased mortality
Higher cumulative doses correlated with greater mortality risk
Confounding factors complicate causal attribution

Abstract

Chronic oral GC exposure was associated with increased mortality across disease groups, with higher cumulative and early-treatment doses correlating with higher risk. However, causal attribution remains uncertain due to confounding by indication, limited disease-severity data, and exposure misclassification. These findings support glucocorticoid stewardship and targeted cardiovascular and infection risk mitigation, rather than indiscriminate dose reduction.

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