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March 28, 2026Mayo Clinic Proceedings0 citationsOpen Access

Severe α1-Antitrypsin Deficiency and Increased Risk of Gastrointestinal Diseases

AHAdriana-Maria HillerEPEeva PiitulainenMEMagnus Ekström

Key Points

  • This research aims to evaluate the risk of gastrointestinal diseases associated with severe α1-antitrypsin deficiency in individuals with PiZZ.
  • Comparative analysis of individuals with PiZZ and the general population
  • Assessment of gastrointestinal disease prevalence
  • Examination of specific conditions such as Crohn disease and ulcerative colitis.
  • Individuals with PiZZ have a higher incidence of gastrointestinal diseases compared to the general population.
  • Specific diseases include Crohn disease, ulcerative colitis, and diverticular disease.

Abstract

Individuals with PiZZ have an increased risk for development of gastrointestinal diseases (Crohn disease, ulcerative colitis, noninfectious gastroenteritis, and diverticular disease encompassing symptomatic diverticulosis and its complications), as compared with the general population.

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Cite This Study

Hiller et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e0753https://doi.org/10.1016/j.mayocp.2025.11.017
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