Potassium binders and continuation of renin–angiotensin system inhibitors/mineralocorticoid receptor antagonist in chronic kidney disease and heart failure (the DEMONSTRATE database)

Key Result

Second-generation potassium binders were associated with higher RAASi persistence than first-generation binders, which was linked to lower mortality and hospitalization in CKD and heart failure.

Key Points

• This research investigates the impact of potassium binders on the persistence of RAAS inhibitors in patients with chronic kidney disease and heart failure.
• Analyzed data from the DEMONSTRATE database
• Compared second-generation and first-generation potassium binders
• Evaluated all-cause mortality and hospitalization rates
• Assessed 3P-MACE rates associated with RAASi persistence
• Second-generation potassium binders showed higher RAAS inhibitor persistence than first-generation options
• Higher RAASi persistence linked to lower all-cause mortality and hospitalization rates
• No significant differences found in 3P-MACE rates between the groups.