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March 28, 2026Annals of Medicine1 citationsOpen Access

Cuproptosis in spinal cord injury: emerging mechanisms and immunological relevance

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LLL. LiJZJie-Qi ZhangXYXi-han Ying

Key Points

  • Investigate cuproptosis mechanisms in spinal cord injury and their impact on the immune response.
  • Explored cuproptosis pathways involved in secondary injury after spinal cord damage.
  • Analyzed the immune microenvironment changes related to cuproptosis.
  • Evaluated potential therapeutic strategies targeting copper homeostasis.
  • Identified cuproptosis as a significant factor in immune remodeling following spinal cord injury.
  • Demonstrated that restoring copper levels may enhance healing processes and immune responses.

Abstract

Cuproptosis plays an important role in SCI secondary injury and immune microenvironment remodeling. Targeting cuproptosis related pathways and restoring copper homeostasis may provide promising strategies for precision therapy.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c772938bbfbc51511e323chttps://doi.org/10.1080/07853890.2026.2641867
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