Successful treatment of primary mediastinal malignant germ cell tumor with multiple systemic metastases in children using multi-drug combination chemotherapy: a rare case report

Primary mediastinal malignant germ cell tumors (PMMGCTs) in children are highly aggressive and associated with a poor prognosis. We herein report the case of a male pediatric patient who presented with a large mediastinal mass and extensive metastases to the lungs, brain, kidneys, and multiple bones, illustrating the aggressive nature of this disease. The patient received a multi-drug combination chemotherapy regimen before and after tumor resection and successfully achieved complete remission. Notably, he has survived for 12 months and remains in complete remission to date. This case underscores the potential efficacy of multi-agent combination chemotherapy as a component of a multimodal treatment strategy for advanced PMMGCTs.