The diagnostic evaluation of progressive, multifocal sensory neuropathy can be challenging and prone to misdirection without a broad differential diagnosis and a careful clinical history. We present a 41-year-old healthy man with insidious onset of right foot paresthesia, which gradually extended to his left foot and right hand over several months. This case illustrates a systematic clinical reasoning approach to multifocal neuropathy, culminating in the unexpected diagnosis of a treatable cause for neuropathy. The case underscores the importance of maintaining diagnostic openness to rare but treatable causes in the evaluation of atypical neuropathy presentations.
Lu et al. (2026) studied this question.