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March 31, 2026Physica Medica1 citationsOpen Access

Dosimetric comparison of intensity modulated proton therapy and knowledge-based volumetric arc therapy for left-sided breast cancer

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LHL.K. HuynhSPS.N. PenfoldCSC. Stanton

Key Points

  • To compare the dosimetric outcomes of intensity modulated proton therapy and knowledge-based volumetric arc therapy for treating left-sided breast cancer.
  • Conducted a dosimetric comparison of treatment plans for left-sided breast cancer.
  • Evaluated dose distributions of intensity modulated proton therapy (IMPT) and volumetric arc therapy (VMAT).
  • Assessed cardiac exposure parameters, particularly mean heart dose.
  • IMPT plans demonstrated statistically significant dose reductions compared to VMAT plans.
  • DIBH (deep inspiration breath hold) with KB VMAT showed low mean heart doses, indicating potential cardiac safety.
  • Findings suggest that while IMPT reduces dose, it might not confer a clinical advantage over VMAT due to cardiac risks.

Abstract

Although statistically significant dose reductions for IMPT plans relative to VMAT were reported, the low mean heart doses observed with DIBH KB VMAT plans may limit clinical benefit when considering adverse cardiac events.

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Cite This Study

Huynh et al. (2026) studied this question.

synapsesocial.com/papers/69cb645fe6a8c024954b8949https://doi.org/10.1016/j.ejmp.2026.105774
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