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May 10, 2001New England Journal of Medicine4,596 citations

Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

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RNRobert M. NeerCAClaude D. ArnaudJZJosé Zanchetta

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Abstract

Treatment of postmenopausal osteoporosis with parathyroid hormone (1-34) decreases the risk of vertebral and nonvertebral fractures; increases vertebral, femoral, and total-body bone mineral density; and is well tolerated. The 40-microg dose increased bone mineral density more than the 20-microg dose but had similar effects on the risk of fracture and was more likely to have side effects.

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Neer et al. (2001) studied this question.

synapsesocial.com/papers/69cc81003e618bf1a7242d17https://doi.org/10.1056/nejm200105103441904
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcitriol Treatment Is Not Effective in Postmenopausal Osteoporosis1989 · 310 citations
  2. 2Sequential Parathyroid Hormone/Alendronate Therapy for Osteoporosis--Robbing Peter to Pay Paul?2000 · 18 citations
  3. 3Effect of Intermittent Cyclical Etidronate Therapy on Bone Mass and Fracture Rate in Women with Postmenopausal Osteoporosis1990 · 942 citations
  4. 4Mice, Estrogen, and Postmenopausal Osteoporosis1999 · 85 citations
  5. 5Parathyroid Hormone Stimulates the Bone Apposition Rate Independently of Its Resorptive Action: Differential Effects of Intermittent and Continuous Administration*1982 · 616 citations