According to Ayurveda, Dosha, Dhatu and Mala are vital for maintaining health and any imbalanceleads to disease. This topic is important as it bridges traditional Ayurvedic wisdom with modernphysiology, enhancing understanding of disease and treatment. Among these, Dhatu plays a key role in sustaining health. When Dhatus are balanced and in proper proportion, the body remains stable astate called Samayogavahi, reflecting internal homeostasis. Ayurveda’s Loka-Purusha Samya and Panchbhautik Siddhantas explain that both body and universe consist of five elements working together to maintain homeostasis. Dhatus, like Rasa, Rakta etc. embody these elements. Ayurvedic treatment applies Samanya-Vishesha Siddhanta to correct Dhatuvaishamya by balancing Vruddhi and Kshaya. Balanced Ahara, Vihara and Agni sustain Samayoga by regulating Doshas, Dhatus and Malas. While factors like Desha, Kala, Vaya and Prakriti affect this balance. Dhatuposhana Nyaya illustrates sequential metabolism controlled by Dhatvagni and Jatharagni to maintain Dhatusamyata. Hormones regulate tissue activity and Vipakas balance Doshas, preserving harmony between anabolic and catabolic processes. Practices like Dinacharya, Ritucharya and Prakriti-based routines help maintain homeostasis. Acharya Charak states that Ayurveda aims to maintain health by preserving Dhatusamya and treating Dhatuvaishamya. Loka-Purusha Samya Siddhanta shows that both universe and human body share same elements, through Samanya-Vishesha Siddhanta balance is maintained. This principle reflects harmony between humans and nature, supporting internal and ecological balance.
2Dr. Manisha Sharma 1Dr. Gursharan Singh (2026) studied this question.