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April 1, 2026Advances in Therapy0 citationsOpen Access

Safety and Effectiveness Analysis of Dolutegravir and Dolutegravir/Abacavir/Lamivudine in Japanese People Living with HIV: 10 years of Post-Marketing Surveillance

ASAkemi SebataTNTakako NagaoTMTomoko Matsukawa

Key Points

  • The aim was to evaluate the long-term safety and effectiveness of dolutegravir and its combinations in Japanese individuals living with HIV.
  • Conducted a 10-year post-marketing surveillance study
  • Analyzed safety and effectiveness profiles of dolutegravir and combinations
  • Monitored for new safety concerns
  • No new safety concerns were identified during the surveillance period
  • Continued support for the established safety profiles of the drugs
  • Reinforcement of their role as key therapeutic options in clinical practice

Abstract

This 10-year post-marketing surveillance confirms the long-term safety and effectiveness of single-agent DTG and DTG/ABC/3TC in Japanese PLHIV. No new safety concerns emerged over the 10-year surveillance period, further supporting their established safety profiles and reinforcing their continued role as key therapeutic options in routine clinical practice.

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Cite This Study

Sebata et al. (2026) studied this question.

synapsesocial.com/papers/69ccb74216edfba7beb89184https://doi.org/10.1007/s12325-026-03544-0
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