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April 1, 2026Clinical Toxicology4 citationsOpen Access

Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose

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LHLotte C. G. HoegbergSGSophie GosselinNBNicholas A. Buckley

Key Points

  • To evaluate the timing and dosing of activated charcoal for effective treatment in cases of acute oral overdose.
  • Review of existing treatment guidelines
  • Assessment of specific poison types and clinical scenarios
  • Recommendation for single and multiple doses of activated charcoal
  • Single-dose activated charcoal can be administered after 1 hour in certain poisonings.
  • Additional doses may help prevent further absorption of toxins.
  • Multiple-dose activated charcoal may improve elimination in specific cases.

Abstract

The Workgroup recommends the administration of a single-dose of activated charcoal beyond the traditional 1 h post-ingestion time point in selected poisons and introduces the concept of an additional dose of activated charcoal to prevent further absorption of poisons that may remain in the gastrointestinal tract for prolonged periods of time. Multiple-dose activated charcoal is also recommended to enhance elimination in selected clinical scenarios.

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Cite This Study

Hoegberg et al. (2026) studied this question.

synapsesocial.com/papers/69ccb75916edfba7beb893c8https://doi.org/10.1080/15563650.2025.2609807
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  1. 1Pharmacokinetic–pharmacodynamic modelling of QT interval prolongation following citalopram overdoses2005 · 92 citations
  2. 2Does Multiple-Dose Charcoal Therapy Enhance Salicylate Excretion?1990 · 30 citations
  3. 3Increased transport of theophylline into gastrointestinal lumen and gastrointestinal dialysis by activated charcoal in rats with hepatic cirrhosis.1989 · 10 citations
  4. 4Adsorption of Imipramine onto Activated Charocoal and a Cation Exchange Resin in Macrogol-Electrolyte Solution.1992 · 13 citations
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