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April 1, 2026Open Access

QBD Based Stability Indicating Rp-HPLC Method for Combined Antiretroviral Tablets

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Authors

SRSridevi Pulakanam1*, Kumbha Prathyusha2, Mule Venkatachennakesavareddy3, Mangalapudi Rami Reddy4, Maruprolu Anil Kumar Reddy5

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Overview

This method estimates drug levels in combined antiretroviral tablets, indicating effective analysis techniques.

Key Points

  • The aim is to develop and validate a reliable RP-HPLC method for estimating multiple drugs in combined antiretroviral tablets.
  • Utilized a two-level full factorial design for chromatographic optimization.
  • Optimized conditions included a column type and organic phase percentage.
  • Set flow rate at 1 ml/min and volume of injection at 20 µl.
  • Retention times were 3.785 min for Dolutegravir, 1.529 min for Lamivudine, and 3.140 min for Tenofovir.
  • R2 values indicated excellent linearity: 0.99985 for Dolutegravir, 0.99994 for Lamivudine, and 0.99923 for Tenofovir.
  • Percentage RSD of peak areas was less than 2.0, confirming method precision.

Cite This Study

Sridevi Pulakanam1*, Kumbha Prathyusha2, Mule Venkatachennakesavareddy3, Mangalapudi Rami Reddy4, Maruprolu Anil Kumar Reddy5 (2026) studied this question.

synapsesocial.com/papers/69ccb76c16edfba7beb89662https://doi.org/10.5281/zenodo.19330135
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