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April 3, 2026Biomaterials Science0 citations

Supramolecular RNAi with Multifunctional siRNA Nanostructures

DSDavid A. SabatinoMSMichael ShaikhetJOJoshua O'Grady

Key Points

  • The aim is to explore the potential of supramolecular RNA nanostructures as genetic tools in gene silencing.
  • Developed discrete RNA building block monomers.
  • Facilitated self-assembly into multifaceted siRNA nanostructures.
  • Evaluated the efficacy in gene silencing applications.
  • Demonstrated effective gene silencing using the engineered siRNA nanostructures.
  • Showed successful self-assembly of distinct RNA components.
  • Highlighted potential applications in various biomedical fields.

Abstract

Supramolecular RNA nanostructures have recently emerged as powerful genetic tools in biomedical applications. The modular design of discrete RNA building block monomers for the self-assembly of genetically encoded short interfering...

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Cite This Study

Sabatino et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d4e5a333a821460b060https://doi.org/10.1039/d5bm01877c
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