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April 3, 2026Cell Reports Medicine1 citationsOpen Access

Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8+ T cell immunity via rewiring MHC-I antigen presentation

HFHuolun FengGuangdong Academy of Medical SciencesYZYuhan ZhangStony Brook SchoolZHZuda HuangGuangdong Academy of Medical Sciences

Key Points

  • This research aims to determine how an engineered oncolytic virus impacts CD8+ T cell immunity through MHC-I antigen presentation.
  • Developed an oncolytic virus armed with anti-PCSK9 scFv
  • Measured long-term CD8+ T cell responses
  • Analyzed changes in MHC-I antigen presentation
  • Significant increase in long-term CD8+ T cell immunity observed
  • Enhanced MHC-I antigen presentation correlated with improved immune responses

Abstract

Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8 + T cell immunity via

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d775a333a821460b3cahttps://doi.org/10.1016/j.xcrm.2026.102724
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