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April 3, 2026Brain and Behavior0 citationsOpen Access

Integrative Multi‐Omics Mendelian Randomization Highlights Causal Autophagy‐Related Genes for Amyotrophic Lateral Sclerosis

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ZJZheng JiangYRYan‐Lin RenXGXiao‐Jing Gu

Key Points

  • To explore causal relationships between autophagy-related genes and amyotrophic lateral sclerosis (ALS) risk.
  • Conducted a multi-omics mendelian randomization (MR) analysis.
  • Evaluated regulation of four specific autophagy-related genes.
  • Analysed data to uncover associations with ALS risk.
  • Identified significant causal associations between autophagy genes and ALS risk.
  • Provided evidence suggesting the role of autophagy in ALS mechanisms.
  • Highlighted potential therapeutic targets for ALS interventions.

Abstract

This multi-omics MR study identified causal associations between the regulation of four autophagy-related genes and ALS risk, shedding light on autophagy-mediated mechanisms and offering early evidence of novel therapeutic targets for ALS.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69cf5dc55a333a821460bb11https://doi.org/10.1002/brb3.71366
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