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April 3, 2026Chemical Communications0 citations

Conformational Plasticity of Holliday Junctions Tunes Histone H1-Mediated Liquid-Liquid Phase Separation

JMJiaqi MaoYBYunqiang BianYLYang Li

Key Points

  • The study aims to understand how the dynamics of Holliday junctions influence histone H1-mediated phase separation.
  • Conducted experiments on Holliday junctions to measure branch-migration kinetics.
  • Analyzed the role of histone H1 in the condensation process.
  • Examined the impact of multivalent electrostatics on liquid-liquid phase separation.
  • Holliday junction branch-migration kinetics significantly influence histone H1-mediated condensation.
  • H1 increases the rate of conformational change, enhancing phase separation.
  • Findings demonstrate that DNA dynamics play a crucial role in the phase separation process.

Abstract

Liquid-liquid phase separation is often attributed to multivalent electrostatics, yet how DNA dynamics contribute remains unresolved. We show that Holliday junction branch-migration kinetics control histone H1-mediated condensation: H1 accelerates conformational...

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Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/69cf5dc55a333a821460bc13https://doi.org/10.1039/d5cc07343j
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