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April 4, 2026The Journals of Gerontology Series A1 citations

Sleep architecture and self-reported sleep quality are associated with Alzheimer’s disease biomarkers in older adults without dementia

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SLSofia LiuJHJing HuangRCRussell Calderon

Key Points

  • This research aims to examine the relationship between sleep architecture, self-reported sleep quality, and Alzheimer's disease biomarkers in older adults without dementia.
  • Measured REM sleep architecture using ambulatory EEG.
  • Evaluated plasma amyloid profiles in participants.
  • Assessed subjective sleep quality through self-reports.
  • Greater REM sleep correlated with a more favorable plasma amyloid profile.
  • Associations between subjective sleep quality and plasma biomarkers were nominal.
  • Findings indicate sensitivity of REM sleep architecture to amyloid-related changes.

Abstract

Greater REM sleep was associated with a more favorable plasma amyloid profile, whereas associations between subjective sleep quality and plasma biomarkers were nominal and require confirmation in larger studies. These findings suggest that REM sleep architecture measured using ambulatory EEG may be particularly sensitive to amyloid-related changes prior to dementia.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69d0af1c659487ece0fa5029https://doi.org/10.1093/gerona/glag081
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