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April 5, 2026From Chemistry Towards Technology Step-By-Step0 citationsOpen Access

In silico profilirovanie proizvodnykh 3,4-digidro-1H-1,4oksazino4,3-abenzimidazola: prognoz tsitotoksicheskikh svoistv i ADME-profilya

YAYuliya AleksandrovaMKMaria KucherenkoISInna Shagina

Key Points

  • The research aims to predict the cytotoxic properties and ADME profiles of certain benzimidazole compounds using in silico methods.
  • Utilized in silico profiling to analyze chemical properties
  • Applied LD50 calculations to assess toxicity
  • Evaluated ADME (Absorption, Distribution, Metabolism, Excretion) characteristics
  • Identified LD50 values ranging from 10 to 1500 mg/kg
  • Predicted favorable ADME profiles for the tested compounds
  • Establish correlations between chemical structure and cytotoxicity

Abstract

. 3,4--1H-4,3-a, , SEAr. in silico . II IV LD50 10-1500 /. . ADME- , in vitro .

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Cite This Study

Aleksandrova et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc28a79560c99a0a1c2bhttps://doi.org/10.52957/2782-1900-2026-7-1-84-92
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