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April 5, 2026Pediatric Pulmonology1 citations

The Impact of Elexacaftor/Tezacaftor/Ivacaftor on Fat‐Soluble Vitamin Status and Supplementation in a Pediatric Cystic Fibrosis Cohort

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FKFern KimberDSD. Sills

Key Points

  • To evaluate the effect of elexacaftor/tezacaftor/ivacaftor (ETI) on fat-soluble vitamin status in pediatric cystic fibrosis patients.
  • Evaluated vitamin levels before and after ETI initiation
  • Assessed necessity for fat-soluble vitamin supplementation
  • Compared vitamin A and E levels pre and post ETI
  • Vitamin D levels increased significantly after ETI initiation
  • Reduced requirement for fat-soluble vitamin supplementation noted
  • No significant increase in Vitamin A and E levels, yet Vitamin A supplementation appears more effective

Abstract

This study found following ETI initiation vitamin D levels increased, and the requirement for fat-soluble vitamin supplementation appeared to decrease. Whilst ETI was not associated with increased Vitamin A and E, the burden of supplementation decreased, and Vitamin A supplementation maybe more effective.

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Cite This Study

Kimber et al. (2026) studied this question.

synapsesocial.com/papers/69d1fca7a79560c99a0a2479https://doi.org/10.1002/ppul.71596
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