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April 5, 2026Cancer Research0 citations

Preventing NK Cell Activation Enhances Survival in Advanced Hepatocellular Carcinoma Models

Abstract 3793: Preventing nk cell activation in the damaged liver induced by cabozantinib/pd-1 blockade increases survival in hepatocellular carcinoma models

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Authors

SMSatoru MoritaTATomofumi AndoHKHiroto Kikuchi

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Overview

Research reveals that blocking NK cell activation improves survival in liver-damaged hepatocellular carcinoma models, indicating a potential treatment strategy.

Key Points

  • The study aims to understand why combining cabozantinib with immune checkpoint blockade fails in liver-damaged hepatocellular carcinoma.
  • Utilized orthotopic murine models of hepatocellular carcinoma with varying liver conditions.
  • Monitored tumor growth, liver function, and survival outcomes.
  • Conducted immune profiling of intra-tumoral and liver environments.
  • Cabozantinib/ICB treatment led to tumor regression and improved survival in normal liver conditions.
  • In mice with liver fibrosis, the combination treatment did not enhance survival despite similar tumor control.
  • Depletion of NK cells reduced hepatotoxicity and improved survival in liver-damaged mice receiving combination therapy.
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Morita et al. (2026) studied this question.

synapsesocial.com/papers/69d1fcc0a79560c99a0a264dhttps://doi.org/10.1158/1538-7445.am2026-3793
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