What question did this study set out to answer?

This research investigates the effects of NAMPT inhibition on cellular viability, energy metabolism, and DNA integrity in neuroblastoma models.

Abstract 4568: Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) impairs cellular viability, affects energy metabolism, induces DNA damage, and drives tumor regression in preclinical models of neuroblastoma

View Full Paper

Ask AI

Bookmark

Authors

Preclinical models show NAMPT inhibition impairs viability and induces DNA damage in neuroblastoma, suggesting a new treatment avenue.

This research investigates the effects of NAMPT inhibition on cellular viability, energy metabolism, and DNA integrity in neuroblastoma models.
Conducted a high-throughput screen identifying neuroblastoma cell sensitivity to NAMPT inhibitors.
Validated findings using clinical NAMPT inhibitors in molecularly diverse neuroblastoma cell lines.
Assessed mechanistic effects on NAD+-dependent pathways and analyzed in vivo effects in orthotopic models.
Evaluated cell death mechanisms and effects on NAD+ consuming enzymes including SIRT1 and PARP.
Neuroblastoma cells showed 20-fold higher sensitivity to NAMPT inhibitors compared to other solid tumors.
Treatment resulted in over 90% reduction in ATP levels after 72h.
Both PARP and SIRT1 activities significantly decreased with NAMPTi treatment, leading to increased DNA damage.
In vivo studies showed 67% average tumor volume reduction in orthotopic xenografts.

Yu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

View Full Paper

Ask AI

Bookmark

Authors

Preclinical models show NAMPT inhibition impairs viability and induces DNA damage in neuroblastoma, suggesting a new treatment avenue.

This research investigates the effects of NAMPT inhibition on cellular viability, energy metabolism, and DNA integrity in neuroblastoma models.
Conducted a high-throughput screen identifying neuroblastoma cell sensitivity to NAMPT inhibitors.
Validated findings using clinical NAMPT inhibitors in molecularly diverse neuroblastoma cell lines.
Assessed mechanistic effects on NAD+-dependent pathways and analyzed in vivo effects in orthotopic models.
Evaluated cell death mechanisms and effects on NAD+ consuming enzymes including SIRT1 and PARP.
Neuroblastoma cells showed 20-fold higher sensitivity to NAMPT inhibitors compared to other solid tumors.
Treatment resulted in over 90% reduction in ATP levels after 72h.
Both PARP and SIRT1 activities significantly decreased with NAMPTi treatment, leading to increased DNA damage.
In vivo studies showed 67% average tumor volume reduction in orthotopic xenografts.

Yu et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark