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April 5, 2026Cancer Research

Modifiable factors account for ~92% of identified risks linked to cancer incidence.

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Why the study?

While many studies had evaluated specific risk-cancer pairs, none had estimated the entire network of risks across cancer types.

Population

Cohort studies between 1980 and 2024 from CanRisk-DB

Comparison

144 cancer-related risk factors across 39 cancer types

Design

AI-driven systematic review and meta-analysis

Key result

Evaluation of 144 risk factors across 39 cancer types identified 2,388 risk-cancer associations, with 92.4% of the identified risk factors being modifiable.

Authors

CXChangfa XiaSTShiyuan TongYXYan Xu

Discussion

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Member takes

Overview

Reinforces alcohol minimization in cancer prevention counseling; confirms consistency with prior meta-analyses via AI-driven mapping.

Key Points

  • Quantify the associations between 144 cancer-related risk factors and 39 cancer types to enhance understanding of cancer incidence.
  • Utilized risk records from CanRisk-DB for analysis.
  • Employed AI-driven graph-based retrieval with a systematic review framework.
  • Meta-analyzed effect sizes from cohort studies spanning 1980 to 2024.
  • Validated findings against existing published meta-analyses.
  • Identified 2,388 risk-factor and cancer-type combinations.
  • 92.4% of risk factors were modifiable; 67 identified as causal.
  • Alcohol consumption linked positively to multiple cancers but inversely to kidney cancer.
  • 34 cancers associated with at least 5 risks and 20 with at least 15 risks.

Study Design

Type

Meta-Analysis

Structured PICO

P
Population
Cohort studies between 1980 and 2024 from CanRisk-DB examining cancer incidence
I
Intervention
144 cancer-related risk factors
O
Outcome
Cancer incidence (relative risks or hazard ratios)

An AI-driven meta-analysis successfully mapped 2,388 associations between 144 risk factors and 39 cancer types, demonstrating high consistency with published meta-analyses.

Cite This Study

Xia et al. (2026) conducted a meta-analysis in Cancer. 144 incidence risk factors was evaluated on Cancer incidence. Evaluation of 144 risk factors across 39 cancer types identified 2,388 risk-cancer associations, with 92.4% of the identified risk factors being modifiable.

synapsesocial.com/papers/69d1fcd4a79560c99a0a295ehttps://doi.org/10.1158/1538-7445.am2026-2337
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4968: Discovery of cancer-associated factors in 293.5 million diagnosis records using statistical machine learning analysis2024
  2. 2CanRisk-DB: an artificial intelligence-driven comprehensive database of cancer risk factors2025 · 1 citations
  3. 3CanRisk-DB: an artificial intelligence-driven comprehensive database of cancer risk factors2025
  4. 4Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers2024 · 16 citations
  5. 5Abstract 3586: Validation and population projection of multi-cancer risk incorporating polygenic risk scores and non-genetic factors.2026