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April 5, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

“Eye-Conic” Spatial Transcriptomics Reveals the Layer-Specific Molecular Alterations in Corneas of Patients With Keratoconus

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AWA WysockaKJKatarzyna Jaskiewicz-RajewiczJWJakub Wozniak

Key Points

  • This research aims to examine the molecular changes in different layers of corneas affected by keratoconus.
  • Utilized spatial transcriptomics to analyze corneal tissue samples
  • Identified molecular alterations across various corneal layers
  • Investigated intercellular communication patterns in keratoconus samples
  • Revealed specific molecular changes in the layers of corneas affected by keratoconus
  • Demonstrated altered intercellular communication patterns associated with cone formation mechanisms

Abstract

Findings regarding the corneal layers and the intercellular communication patterns in KTCN corneas allowed for further understanding of the cone formation mechanism.

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Cite This Study

Wysocka et al. (2026) studied this question.

synapsesocial.com/papers/69d1fceba79560c99a0a2965https://doi.org/10.1167/iovs.67.4.7
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