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April 5, 2026Environmental Science Advances2 citationsOpen Access

A Scoping Literature Review of Toxicological Studies on Per- and Polyfluoroalkyl Substances (PFAS)

MPMarianthi PapathanasiouHTHaralampos TzoupisKPKonstantinos D. Papavasileiou

Key Points

  • The review aims to summarize existing literature on the toxicological effects of PFAS and their environmental impact.
  • Conducted a scoping literature review on PFAS-related toxicological studies.
  • Analyzed chemical structures and resistance to degradation.
  • Evaluated the implications for environmental safety and health.
  • PFAS exhibit strong environmental persistence due to carbon-fluorine bonds.
  • Many toxicological studies highlight the health risks associated with PFAS exposure.
  • Evidence suggests that PFAS accumulate in living organisms, raising concerns for ecosystems.

Abstract

Per- and Polyfluoroalkyl substances (PFAS) encompass a diverse group of industrial chemicals resistant to both environmental degradation and metabolic breakdown due to the strong carbon-fluorine (C-F) bonds dominating their structures...

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Cite This Study

Papathanasiou et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd62a79560c99a0a35a5https://doi.org/10.1039/d5va00328h
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review of Environmental Distribution, Health Impacts, and Regulatory Landscape2025
  2. 2Human Exposure Pathways to Per- and Polyfluoroalkyl Substances (PFASs)—A Comprehensive Review of Sources, Physicochemical Properties, and Human Health Risk Assessment2026 · 2 citations
  3. 3Toxicological Effects and Health Impacts of Per- and Polyfluoroalkyl Substances (PFAS) in Humans2026 · 2 citations
  4. 4PFAS behavior in the environment: transport pathways, physicochemical properties, and emerging precursors2026 · 2 citations
  5. 5Sonochemical degradation of per- and polyfluoroalkyl substances (PFAS): mechanisms, efficacy, and future directions2026 · 1 citations