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April 5, 2026Medicine & Science in Sports & Exercise0 citations

Acute Aerobic Walking Exercise Induces Changes in Thalamic Resting-State Connectivity in Persons with Multiple Sclerosis

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BSBrian M. SandroffRMRobert W. MotlHNHaley Nauman

Key Points

  • To investigate how acute aerobic walking exercise affects thalamic resting-state connectivity in individuals with multiple sclerosis.
  • Performed single bouts of aerobic walking exercise
  • Assessed thalamic resting-state functional connectivity (RSFC)
  • Compared effects based on multisensory input from overground walking (OG) versus treadmill (TM) walking.
  • Observed significant changes in thalamic RSFC linked to cognitive functions
  • Changes varied between overground and treadmill walking conditions
  • Suggests aerobic walking may enhance cognitive processes in MS.

Abstract

This study provides the first empirical evidence that single bouts of aerobic walking exercise induce changes in thalamic RSFC across several regions that are important for cognition in MS, and this differed based on multisensory input associated with OG versus TM. Such evidence provides important insight into potential mechanisms for why aerobic walking exercise might improve cognition in persons with MS.

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Cite This Study

Sandroff et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe68a79560c99a0a4af2https://doi.org/10.1249/mss.0000000000003998
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