July 27, 2010Circulation280 citationsOpen Access
Correlates of Echocardiographic Indices of Cardiac Remodeling Over the Adult Life Course
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Structured PICO
P
Population
Adults
O
Outcome
Echocardiographic indices of cardiac remodeling (LV wall thickness, LV dimensions, and fractional shortening)surrogate
Female sex, higher blood pressure, and diabetes attenuate normal age-related cardiac remodeling, potentially explaining their strong association with diastolic heart failure.
Abstract
Cardiac remodeling over the adult life course is characterized by a distinct pattern of increasing LV wall thickness, decreasing LV dimensions, and increasing fractional shortening with advancing age. Overall, female sex, greater blood pressure load, and presence of diabetes mellitus serve to attenuate this remodeling pattern. These observations suggest a mechanism for the preponderance of women with hypertension and individuals with diabetes among patients with diastolic heart failure.
Cite This Study
Cheng et al. (2010) studied this question.