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January 23, 2014Circulation342 citationsOpen Access

Warfarin Use and the Risk for Stroke and Bleeding in Patients With Atrial Fibrillation Undergoing Dialysis

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MSMitesh ShahWestern UniversityMTMeytal Avgil TsadokIsrael Ministry of HealthCJCynthia A. JackeviciusPreventive Cardiology

Structured PICO

Does warfarin reduce stroke risk or increase bleeding risk in patients with atrial fibrillation undergoing dialysis?

P
Population
Patients with atrial fibrillation (AF) undergoing dialysis
I
Intervention
Warfarin
O
Outcome
Stroke risk and bleeding riskhard clinical

In patients with atrial fibrillation on dialysis, warfarin does not reduce stroke risk but significantly increases the risk of bleeding.

Abstract

Our results suggest that warfarin use is not beneficial in reducing stroke risk, but it is associated with a higher bleeding risk in patients with AF undergoing dialysis.

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Cite This Study

Shah et al. (2014) studied this question.

synapsesocial.com/papers/69d56dde75589c71d767d15dhttps://doi.org/10.1161/circulationaha.113.004777
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Warfarin Use and Risk of Stroke in Patients With Atrial Fibrillation Undergoing Hemodialysis2016 · 28 citations
  2. 2Effectiveness and Safety of Warfarin in Dialysis Patients With Atrial Fibrillation2015 · 29 citations
  3. 3Warfarin Use in Hemodialysis Patients With Atrial Fibrillation: A Systematic Review of Stroke and Bleeding Outcomes2017 · 12 citations
  4. 4Warfarin in haemodialysis patients with atrial fibrillation: what benefit?2010 · 66 citations
  5. 5Efficacy and safety of warfarin in dialysis patients with atrial fibrillation: a systematic review and meta-analysis2016 · 50 citations