Is coronary microvascular dysfunction associated with the acute phase of takotsubo-like transient left ventricular dysfunction?
Transient coronary microvascular dysfunction, evidenced by reversible impairment in CFVR and DDT, may be a causative mechanism in takotsubo-like left ventricular dysfunction.
Decreased CFVR and short DDT were demonstrated in patients with takotsubo-like transient LV dysfunction in the acute phase, and these findings improved 3 weeks later, which suggests that coronary microvascular dysfunction may be a causative mechanism.
Kume et al. (2005) studied this question.