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January 1, 1995Circulation532 citations

Previous Angina Alters In-Hospital Outcome in TIMI 4

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Robert A. Kloner
Robert A. KlonerGeneral / Preventive / Lipids
TSThomas ShookNorthwestern MedicineKPKarin PrzyklenkCross-Cutting Cardiology

Structured PICO

Does previous angina improve in-hospital outcome after acute myocardial infarction?

P
Population
Patients with acute myocardial infarction (TIMI 4)
I
Intervention
Previous angina
O
Outcome
In-hospital outcome

Previous angina is associated with better in-hospital outcomes following acute myocardial infarction, possibly due to ischemic preconditioning.

Abstract

Previous angina confers a beneficial effect on in-hospital outcome after acute myocardial infarction. The reasons for this benefit are uncertain, but one potential mechanism for this observation may be ischemic preconditioning.

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Cite This Study

Kloner et al. (1995) studied this question.

synapsesocial.com/papers/69d570be75589c71d767ded7https://doi.org/10.1161/01.cir.91.1.37
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 4 trial1994 · 180 citations
  2. 2Effect of ischemic preconditioning on regional myocardial flow in the rabbit heart1992 · 49 citations
  3. 3Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.1986 · 7,837 citations
  4. 4Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.1993 · 1,000 citations
  5. 5MYOCARDIAL ISCHAEMIA DURING DAILY LIFE IN PATIENTS WITH STABLE ANGINA: ITS RELATION TO SYMPTOMS AND HEART RATE CHANGES1983 · 721 citations