PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 9, 2013New England Journal of Medicine580 citationsOpen Access

Pacemaker or Defibrillator Surgery without Interruption of Anticoagulation

View Full Paper
DBDavid H. BirnieJHJeff S. HealeyGWGeorge A. Wells

Key Points

  • The aim is to compare the effects of continued warfarin vs. bridging therapy with heparin during pacemaker or ICD surgery.
  • Randomized trial comparing continued warfarin treatment versus heparin bridging therapy.

Structured PICO

Does continued warfarin treatment reduce the incidence of clinically significant device-pocket hematoma in patients undergoing pacemaker or ICD surgery compared to bridging therapy with heparin?

P
Population
Patients undergoing pacemaker or implantable cardioverter-defibrillator (ICD) surgery
I
Intervention
Continued warfarin treatment
C
Comparator
Bridging therapy with heparin
O
Outcome
Incidence of clinically significant device-pocket hematomasafety

Continuing warfarin during pacemaker or ICD surgery significantly reduces the risk of device-pocket hematoma compared to heparin bridging.

Abstract

As compared with bridging therapy with heparin, a strategy of continued warfarin treatment at the time of pacemaker or ICD surgery markedly reduced the incidence of clinically significant device-pocket hematoma. (Funded by the Canadian Institutes of Health Research and the Ministry of Health and Long-Term Care of Ontario; BRUISE CONTROL ClinicalTrials.gov number, NCT00800137.).

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Birnie et al. (2013) studied this question.

synapsesocial.com/papers/69d5718a75589c71d767e2eahttps://doi.org/10.1056/nejmoa1302946
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Rhythm Device Surgery With Uninterrupted Oral Anticoagulation2013
  2. 2Preparation for pacemaker or implantable cardiac defibrillator implants in patients with high risk of thrombo-embolic events: oral anticoagulation or bridging with intravenous heparin? A prospective randomized trial2009 · 112 citations
  3. 3Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2)2018 · 193 citations
  4. 4Anticoagulation Management in the Perioperative Phase of Implantable Cardioverter Defibrillator Implantation2013 · 10 citations
  5. 5Postoperative Low‐Molecular‐Weight Heparin Bridging Is Associated with an Increase in Wound Hematoma Following Surgery for Pacemakers and Implantable Defibrillators2009 · 98 citations