November 6, 2012New England Journal of Medicine1,376 citationsOpen Access
Reduction in Inappropriate Therapy and Mortality through ICD Programming
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Key Points
- This research aims to determine the effects of different ICD programming on therapy appropriateness and mortality rates.
- Compared ICD therapies programmed for tachyarrhythmias of 200 beats per minute or higher to conventional programming.
Structured PICO
Does high-rate or delayed ICD programming reduce inappropriate therapy and all-cause mortality compared with conventional programming?
P
Population
Patients receiving implantable cardioverter-defibrillator (ICD) therapies
I
Intervention
Programming of ICD therapies for tachyarrhythmias of 200 beats per minute or higher or with a prolonged delay in therapy at 170 beats per minute or higher
C
Comparator
Conventional programming
O
Outcome
Inappropriate therapy and all-cause mortality during long-term follow-uphard clinical
Programming ICDs for higher rate thresholds or prolonged delays safely reduces inappropriate therapies and improves overall survival compared to conventional programming.
Abstract
Programming of ICD therapies for tachyarrhythmias of 200 beats per minute or higher or with a prolonged delay in therapy at 170 beats per minute or higher, as compared with conventional programming, was associated with reductions in inappropriate therapy and all-cause mortality during long-term follow-up. (Funded by Boston Scientific; MADIT-RIT ClinicalTrials.gov number, NCT00947310.).
Cite This Study
Moss et al. (2012) studied this question.