Synergistic Potential of Pandanus Odoratissimus and Curcuma Longa in the Management of Nocturnal Enuresis: A Comprehensive Narrative Review of Botanical, Pharmacological and Formulation Strategies

Background: Nocturnal enuresis represents a complex, multifactorial urological disorder affecting both pediatric and adult populations. Conventional pharmacological interventions often suffer from high relapse rates and compliance issues, prompting the search for age-appropriate, plant-based alternatives. Objective: To systematically review the etiology of nocturnal enuresis and explore the therapeutic justification for a novel dual-herb suspension utilizing Pandanus odoratissimus peduncle and Curcuma longa rhizome. Methods: A comprehensive literature review was conducted to synthesize ethnobotanical data, phytochemical profiles, pharmacological mechanisms, and formulation challenges associated with these plants, particularly emphasizing their relevance in resource-limited settings like Yemen. Discussion: The pathophysiology of enuresis involvesnocturnal polyuria, detrusor overactivity, and impaired sleep arousal. Pandanus odoratissimus offers potent antispasmodic and antidiuretic properties via its alkaloidal and phenolic fractions, effectively stabilizing the detrusor muscle. Conversely, Curcuma longa (rich in curcuminoids) provides robust anti-inflammatory, antioxidant, and neuro-modulatory actions that soothe bladder mucosa and enhance brain-bladder signaling. Combining these botanicals yields a synergistic "dual-lock" mechanism. Furthermore, developing these extracts into specialized pediatric and adult suspensions overcomes critical dosage and palatability barriers. Conclusion: A scientifically formulated dual-herb suspension of P. odoratissimus and C. longa represents a promising, culturally resonant, and highly effective therapeutic strategy for nocturnal enuresis. Further formulation optimization and clinical validations are warranted.