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July 13, 2016New England Journal of Medicine3,246 citationsOpen Access

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

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JZJesse M. ZaretskyÁGÁngel García-DíazDSDaniel Sanghoon Shin

Key Points

  • Investigate the molecular mechanisms and genetic alterations associated with acquired resistance to PD-1 blockade immunotherapy in patients with melanoma.
  • Analyzed tumor tissue and molecular pathways in patients with melanoma who developed acquired resistance following PD-1 blockade immunotherapy.
  • Acquired resistance to PD-1 blockade was associated with defects in interferon-receptor signaling pathways.
  • Defects in antigen presentation pathways were linked to treatment resistance and disease progression.

Abstract

In this study, acquired resistance to PD-1 blockade immunotherapy in patients with melanoma was associated with defects in the pathways involved in interferon-receptor signaling and in antigen presentation. (Funded by the National Institutes of Health and others.).

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Cite This Study

Zaretsky et al. (2016) studied this question.

synapsesocial.com/papers/69d6b4c1733a2b54c8aa80cfhttps://doi.org/10.1056/nejmoa1604958
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