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March 11, 2016Aging CellOpen Access

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

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Why the study?

Does nicotinamide mononucleotide (NMN) supplementation reverse age-associated arterial dysfunction and oxidative stress in old mice?

Population

Old mice and young mice

Comparison

Nicotinamide mononucleotide (NMN) supplementation vs Old control mice without NMN supplementation and…

Design

Preclinical

Authors

NPNatalie E. de PicciottoLGLindsey B. GanoLJLawrence C. Johnson

Discussion

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Overview

NMN may reverse age-related arterial dysfunction in mice; hypothesis-generating and leaves open human translation.

Structured PICO

Does nicotinamide mononucleotide (NMN) supplementation reverse age-associated arterial dysfunction and oxidative stress in old mice?

P
Population
Old mice and young mice
I
Intervention
Nicotinamide mononucleotide (NMN) supplementation
C
Comparator
Old control mice without NMN supplementation and young mice
O
Outcome
Carotid artery endothelium-dependent dilation (EDD), aortic pulse wave velocity (aPWV), elastic modulus (EM), and oxidative stress markers (O2- production, nitrotyrosine)surrogate

NMN supplementation reverses age-related arterial dysfunction and oxidative stress in mice by restoring SIRT1 activity.

Cite This Study

Picciotto et al. (2016) studied this question.

synapsesocial.com/papers/69d6c29c8dca315383ed8d81https://doi.org/10.1111/acel.12461
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